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1

Mutational Evidence Supporting the Involvement of Tripartite Residues His183, Asp185, and His243 in Streptomyces clavuligerus Deacetoxycephalosporin C Synthase for Catalysis

SIM, Janet, SIM, Tiow-Suan

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2000

File:

PDF, 1.40 MB

2000

2

Atypical caseinolytic protease homolog fromPlasmodium falciparumpossesses unusual substrate preference and a functional nuclear localization signal

Wenjie Lin, Maurice Chan, Tiow-Suan Sim

Journal:

Parasitology Research

Year:

2009

Language:

english

File:

PDF, 382 KB

english, 2009

3

PCR cloning, heterologous expression, and characterization of isopenicillin N synthase from Streptomyces lipmanii NRRL 3584

Loke, Paxton, Ng, Chee Pang, Sim, Tiow-Suan

Journal:

Canadian Journal of Microbiology

Year:

2000

File:

PDF, 1.42 MB

2000

4

Catalytic Activity inCephalosporium acremoniumIsopenicillin N Synthase Does Not Involve Glutamine-234

Paxton Loke, Tiow-Suan Sim

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 100 KB

english, 1998

5

Molecular cloning and functional characterisation of VanX, a D-alanyl-D-alanine dipeptidase from Streptomyces coelicolor A3(2)

Ai Lin Tan, Paxton Loke, Tiow-Suan Sim

Journal:

Research in Microbiology

Year:

2002

Language:

english

File:

PDF, 135 KB

english, 2002

6

PCR-mediated screening and cloning of a malate synthase genefrom Streptomyces griseus NCIMB 9001

Paxton Loke, Jenny Wee, Keng Ing Seah, Tiow-Suan Sim

Journal:

World Journal of Microbiology and Biotechnology

Year:

2001

Language:

english

File:

PDF, 595 KB

english, 2001

7

Plasmodium falciparumpossesses a unique dual-specificity serine/threonine and tyrosine kinase, Pfnek3

Huiyu Low, Chun Song Chua, Tiow-Suan Sim

Journal:

Cellular and Molecular Life Sciences

Year:

2012

Language:

english

File:

PDF, 1.04 MB

english, 2012

8

Endorsing functionality of Burkholderia pseudomallei glyoxylate cycle genes as anti-persistence drug screens

Yu Min Lye, Maurice Chan, Tiow-Suan Sim

Journal:

Journal of Molecular Catalysis B: Enzymatic

Year:

2005

Language:

english

File:

PDF, 252 KB

english, 2005

9

A relevant in vitro eukaryotic live-cell system for the evaluation of plasmodial protein localization

Maurice Chan, Doreen S.H. Tan, Siew-Heng Wong, Tiow-Suan Sim

Journal:

Year:

2006

Language:

english

File:

PDF, 3.27 MB

english, 2006

10

Functional analysis of a conserved aspartate D218 in Cephalosporium acremonium isopenicillin N synthase

Paxton Loke, Janet Sim, Tiow-Suan Sim

Journal:

FEMS Microbiology Letters

Year:

1997

Language:

english

File:

PDF, 554 KB

english, 1997

11

Molecular cloning, heterologous expression, and functional characterisation of a malate synthase gene from Streptomyces coelicolor A3(2)

Loke, Paxton, Sim, Tiow-Suan

Journal:

Canadian Journal of Microbiology

Year:

2000

File:

PDF, 329 KB

2000

12

Analysis of a conserved arginine R281L in catalysis in Cephalosporium acremonium isopenicillin N synthase

Paxton Loke, Tiow-Suan Sim

Journal:

FEMS Microbiology Letters

Year:

1998

Language:

english

File:

PDF, 161 KB

english, 1998

13

Site-directed mutagenesis of arginine-89 supports the role of its guanidino side-chain in substrate binding by Cephalosporium acremonium isopenicillin N synthase

Paxton Loke, Tiow-Suan Sim

Journal:

FEMS Microbiology Letters

Year:

1999

Language:

english

File:

PDF, 430 KB

english, 1999

14

Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from Plasmodium falciparum

Maurice Chan, Tiow-Suan Sim

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 1.41 MB

english, 2004

15

Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90

Prodromou, Chrisostomos, Nuttall, James M., Millson, Stefan H., Roe, S. Mark, Sim, Tiow-Suan, Tan, Doreen, Workman, Paul, Pearl, Laurence H., Piper, Peter W.

Journal:

ACS Chemical Biology

Year:

2009

Language:

english

File:

PDF, 4.64 MB

english, 2009

16

Directed evolution and rational approaches to improvingStreptomyces clavuligerusdeacetoxycephalosporin C synthase for cephalosporin production

Kian-Sim Goo, Chun-Song Chua, Tiow-Suan Sim

Journal:

Journal of Industrial Microbiology & Biotechnology

Year:

2009

Language:

english

File:

PDF, 1.10 MB

english, 2009

17

Functional analysis of a conserved aspartate D218 in Cephalosporium acremonium isopenicillin N synthase

Paxton Loke, Janet Sim, Tiow-Suan Sim

Journal:

FEMS Microbiology Letters

Year:

1997

Language:

english

File:

PDF, 335 KB

english, 1997

18

Site-directed mutagenesis of arginine-89 supports the role of its guanidino side-chain in substrate binding by Cephalosporium acremonium isopenicillin N synthase

Paxton Loke, Tiow-Suan Sim

Journal:

FEMS Microbiology Letters

Year:

1999

Language:

english

File:

PDF, 432 KB

english, 1999

19

Mutational analysis of conserved glycines 42 and 256 in Cephalosporium acremonium isopenicillin N synthase

Loke, Paxton, Sim, Tiow-Suan

Journal:

Canadian Journal of Microbiology

Year:

2001

File:

PDF, 928 KB

2001

20

Glutamine-230 influences enzyme solubility but not catalysis in Streptomyces clavuligerus isopenicillin N synthase

Paxton Loke, Tiow-Suan Sim

Journal:

FEMS Microbiology Letters

Year:

1999

Language:

english

File:

PDF, 173 KB

english, 1999

21

Amino acid substitutions affecting protein solubility: high level expression of Streptomyces clavuligerus isopenicillin N synthase in Escherichia coli

Janet Sim, Tiow-Suan Sim

Journal:

Journal of Molecular Catalysis B: Enzymatic

Year:

1999

Language:

english

File:

PDF, 109 KB

english, 1999

22

Elucidation of active site residues of Arabidopsis thaliana flavonol synthase provides a molecular platform for engineering flavonols

Chun Song Chua, Daniela Biermann, Kian Sim Goo, Tiow-Suan Sim

Journal:

Year:

2008

Language:

english

File:

PDF, 248 KB

english, 2008

23

Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585

Boon Seng Soh, Paxton Loke, Tiow-Suan Sim

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

2001

Language:

english

File:

PDF, 242 KB

english, 2001

24

In vitro conversion of penicillin G and ampicillin by recombinant Streptomyces clavuligerus NRRL 3585 deacetoxycephalosporin C synthase

Janet Sim, Tiow-Suan Sim

Journal:

Enzyme and Microbial Technology

Year:

2001

Language:

english

File:

PDF, 114 KB

english, 2001

25

Construction of Streptomyces jumonjinensis isopenicillin N synthase double mutants, Ser119Ala/Glu120Gly and Thr308Ala/Thr309Val, overcomes insoluble expression in Escherichia coli

Esther Wong, Janet Sim, Tiow-Suan Sim

Journal:

Journal of Molecular Catalysis B: Enzymatic

Year:

2001

Language:

english

File:

PDF, 296 KB

english, 2001

26

Histidine-272 of isopenicillin N synthase of Cephalosporium acremonium, which is possibly involved in iron binding, is essential for its catalytic activity

Sim Tiow-Suan, Doreen S.H. Tan

Journal:

FEMS Microbiology Letters

Year:

1994

Language:

english

File:

PDF, 613 KB

english, 1994

27

Corrigendum to: “Differences in biochemical properties of the Plasmodial falcipain-2 and berghepain-2 orthologues: Implications for in vivo screens of inhibitors” [FEMS Microbiol. Lett. 249 (2005) 315–321]

Cheryl Chan, Liuh Ling Goh, Tiow-Suan Sim

Journal:

FEMS Microbiology Letters

Year:

2005

Language:

english

File:

PDF, 167 KB

english, 2005

28

A complete library of amino acid alterations at R306 in Streptomyces clavuligerus deacetoxycephalosporin C synthase demonstrates its structural role in the ring-expansion activity

Kian Sim Goo, Chun Song Chua, Tiow-Suan Sim

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2008

Language:

english

File:

PDF, 285 KB

english, 2008

29

Pfnek3 functions as an atypical MAPKK in Plasmodium falciparum

Huiyu Low, Yu Min Lye, Tiow-Suan Sim

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 371 KB

english, 2007

30

Differences in biochemical properties of the Plasmodial falcipain-2 and berghepain-2 orthologues: Implications for in vivo screens of inhibitors

Cheryl Chan, Liuh Ling Goh, Tiow-Suan Sim

Journal:

FEMS Microbiology Letters

Year:

2005

Language:

english

File:

PDF, 283 KB

english, 2005

31

Analysis of Glutamines in Catalysis inCephalosporium acremoniumIsopenicillin N Synthase by Site-Directed Mutagenesis

Paxton Loke, Tiow-Suan Sim

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 146 KB

english, 1998

32

A novel NADPH-dependent carbonyl reductase of Candida macedoniensis: Purification and characterization

Michihiko Kataoka, Yukiko Doi, Tiow-Suan Sim, Sakayu Shimizu, Hideaki Yamada

Journal:

Archives of Biochemistry and Biophysics

Year:

1992

Language:

english

File:

PDF, 876 KB

english, 1992

33

Cloning and sequence characterisation of falcipain-2 fromPlasmodium falciparumGombak A strain (Malaysia)

Tiow-Suan Sim, Paxton Loke, May Lee, Mulkit Singh, Horst Flotow

Journal:

Parasitology Research

Year:

2001

Language:

english

File:

PDF, 110 KB

english, 2001

34

Molecular basis for thermal properties ofStreptomyces thermovulgarisfumarase C hinge at hydrophilic amino acids R163, E170 and S347

Wenjie Lin, Maurice Chan, Liuh-Ling Goh, Tiow-Suan Sim

Journal:

Applied Microbiology and Biotechnology

Year:

2007

Language:

english

File:

PDF, 203 KB

english, 2007

35

Mutational evidence for the role of serine-283 in Cephalosporium acremonium isopenicillin N synthase

Paxton Loke, Tiow-Suan Sim

Journal:

FEMS Microbiology Letters

Year:

1998

Language:

english

File:

PDF, 159 KB

english, 1998

36

Replacement of Tyrosine-197 and the Corresponding Tyrosine-195 to Isoleucine in Cephalosporium acremonium and Streptomyces clavuligerus Isopenicillin N Synthase

Loke, Paxton, Sim, Tiow-Suan

Journal:

Zeitschrift für Naturforschung C

Year:

2001

File:

PDF, 653 KB

2001

37

Ecology of microalgae in a high rate pond for piggery effluent purification in Singapore

Tiow-Suan Sim, Anthony Goh

Journal:

World Journal of Microbiology and Biotechnology

Year:

1988

Language:

english

File:

PDF, 748 KB

english, 1988

38

Designing New β-Lactams: Implications from Their Targets, Resistance Factors and Synthesizing Enzymes

Goo, Kian-Sim, Sim, Tiow-Suan

Journal:

Current Computer - Aided Drug Design

Year:

2011

Language:

english

File:

PDF, 2.86 MB

english, 2011

39

A Comparison of Three Site-Directed Mutagenesis Kits

Loke, Paxton, Sim, Tiow-Suan

Journal:

Zeitschrift für Naturforschung C

Year:

2001

Language:

english

File:

PDF, 3.42 MB

english, 2001

40

Regulation ofPlasmodium falciparumPfnek3 relies on phosphorylation at its activation loop and at threonine 82

Huiyu Low, Chun Song Chua, Tiow-Suan Sim

Journal:

Cellular and Molecular Life Sciences

Year:

2009

Language:

english

File:

PDF, 383 KB

english, 2009

41

Glutamine-230 influences enzyme solubility but not catalysis in Streptomyces clavuligerus isopenicillin N synthase

Paxton Loke, Tiow-Suan Sim

Journal:

FEMS Microbiology Letters

Year:

1999

Language:

english

File:

PDF, 171 KB

english, 1999

42

Pfnek3: An atypical activator of a MAP kinase in Plasmodium falciparum

Yu Min Lye, Maurice Chan, Tiow-Suan Sim

Journal:

Year:

2006

Language:

english

File:

PDF, 1.30 MB

english, 2006

43

Mutational evidence for the role of serine-283 in Cephalosporium acremonium isopenicillin N synthase

Paxton Loke, Tiow-Suan Sim

Journal:

FEMS Microbiology Letters

Year:

1998

Language:

english

File:

PDF, 157 KB

english, 1998

44

The Invariant F283 and Its Strategic Position in the Hydrophobic Cleft of Streptomyces jumonjinensis Isopenicillin N Synthase Active Site Are Functionally Important

Esther Wong, Janet Sim, Tiow-Suan Sim

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 183 KB

english, 2001

45

Co-chaperones of Hsp90 in Plasmodium falciparum and their concerted roles in cellular regulation

CHUA, CHUN-SONG, LOW, HUIYU, SIM, TIOW-SUAN

Journal:

Year:

2014

Language:

english

File:

PDF, 443 KB

english, 2014

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